Journal article

Multiple receptors converge on H2-Q10 to regulate NK and gamma delta T-cell development

Katharine J Goodall, Angela Nguyen, Aya Matsumoto, Julie R McMullen, Sidonia B Eckle, Patrick Bertolino, Lucy C Sullivan, Daniel M Andrews



Class Ib major histocompatibility complex (MHC) is an extended family of molecules, which demonstrate tissue-specific expression and presentation of monomorphic antigens. These characteristics tend to imbue class Ib MHC with unique functions. H2-Q10 is potentially one such molecule that is overexpressed in the liver but its immunological function is not known. We have previously shown that H2-Q10 is a ligand for the natural killer cell receptor Ly49C and now, using H2-Q10-deficient mice, we demonstrate that H2-Q10 can also stabilize the expression of Qa-1b. In the absence of H2-Q10, the development and maturation of conventional hepatic natural killer cells is disrupted. We also provide evid..

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Awarded by NHMRC

Funding Acknowledgements

This work was supported by an NHMRC project grant (APP1141950) for DMA, LCS and PB and a Career Development Fellowship (CDF) for DMA. PB was also funded by NHMRC project grant ID APP1146677. KG was supported by a Monash University Post-Doctoral Award. We thank the members of the Alfred Medical Research and Education Precinct (AMREP) Flow Cytometry unit for expert assistance. We also thank Mrs Debbie Ramsay for assistance with the parabiosis surgeries and the Monash Animal Research Platform (MARP) and AMREP Animal Services (AAS) for husbandry.