Beyond Penicillin: Rapid Desensitization for Specific Flucloxacillin Hypersensitivity

JC Kwong; K Urbancic; JA Trubiano

Journal article

Beyond Penicillin: Rapid Desensitization for Specific Flucloxacillin Hypersensitivity

JC Kwong, K Urbancic, JA Trubiano

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | AMER SOC MICROBIOLOGY | Published : 2018

DOI: 10.1128/AAC.01371-18

Abstract

Beta-lactam therapy for severe staphylococcal infections is associated with superior outcomes, compared to non-beta-lactam therapy. For patients with immediate hypersensitivity to beta-lactams, desensitization has been widely employed to allow beta-lactam therapy, but published protocols for antistaphylococcal beta-lactams such as flucloxacillin are lacking. Here, we report a case and describe the desensitization protocol successfully used for a patient with isolated flucloxacillin immediate hypersensitivity, for whom a penicillin desensitization protocol would likely have resulted in an adverse drug reaction.

University of Melbourne Researchers

Jason Kwong Author Infectious Diseases

Jason Trubiano Author Infectious Diseases

Related Projects (3)

DEFINING TARGETS FOR ANTIFUNGAL STEWARDSHIP IN IMMUNOCOMPROMISED PATIENTS

Patients with impaired immune systems are at risk of serious fungal infections. Antifungal medicines used to prevent and treat these infecti..

DEVELOPING AND EVALUATING A MULTIMODAL ANTIBIOTIC ALLERGY STRATEGY TO IMPROVE ANTIMICROBIAL STEWARDSHIP IN HIGH-RISK ANTIBIOTIC USAGE POPULATIONS

Antibiotic allergies lead to the use of inferior antibiotics and generation of “superbugs”. Antibiotic allergy testing removes up to 90% of ..

THE METAFIND (METAGENOMICS FOR INFECTIOUS DISEASES) PROJECT: DEVELOPING CLINICAL METAGENOMICSTO IMPROVE THE HEALTHCARE OF PATIENTS WITH INFECTIONS

The MetaFIND (Metagenomics For INfectious Diseases) project is a combined laboratory and clinical study that aims to develop and investigate..

Grants

Awarded by Department of Health | National Health and Medical Research Council

Citation metrics

1Web of Science

1Scopus

1Dimensions

Keywords

Pharmacology & Pharmacy

Life Sciences & Biomedicine