Brain swelling is independent of peripheral plasma cytokine levels in Malawian children with cerebral malaria
Visopo Harawa, Madi Njie, Anne Kessler, Augustine Choko, Benjamin Kumwenda, Sam Kampondeni, Michael Potchen, Kami Kim, Anthony Jaworowski, Terrie Taylor, Wilson Mandala, Karl Seydel, Stephen Rogerson
MALARIA JOURNAL | BMC | Published : 2018
BACKGROUND: Cerebral malaria (CM) is often fatal, and severe brain swelling is a predictor of CM-related mortality. CM is characterized by elevated circulating pro-inflammatory cytokines TNF and IFN-γ and anti-inflammatory cytokine IL-10, however whether cytokine levels correlate with brain swelling severity is unknown. This study therefore was conducted to investigate the relationship between cytokine levels and brain swelling severity in children presenting with CM. METHODS: A total of 195 Malawian children presenting with CM were recruited and had the concentrations of plasma cytokines determined and compared to brain swelling severity, determined by MRI examination, and graded as severe,..View full abstract
Awarded by US National Institutes of Health
This work was partly supported by the National Health and Medical Research Council of Australia and by the US National Institutes of Health (5R01AI034969-14), and the Michigan State University College of Osteopathic Medicine.