The Challenges of Stem Cell Therapy in Myocardial Infarction and Heart Failure and the Potential Strategies to Improve the Outcomes
Bing Hui Wang, Danny Liew, Kevin W Huang, Li Huang, Wenjie Tang, Darren J Kelly, Christopher Reid, Zhongmin Liu
NANO LIFE | WORLD SCIENTIFIC PUBL CO PTE LTD | Published : 2018
Cardiovascular disease remains the single highest global cause of death and a significant financial burden on the healthcare system. Despite the advances in medical treatments, the prevalence and mortality for heart failure remain unacceptably high. New approaches are urgently needed to reduce this burden and improve patient outcomes and quality of life. One such promising approach is stem cell therapy, including embryonic stem cells, bone marrow derived stem cells, induced pluripotent stem cells and mesenchymal stem cells. However, the cardiac microenvironment following myocardial infarction poses huge challenges with inflammation, adequate retention, engraftment and functional incorporatio..View full abstract
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Awarded by National Health and Medical Research Council of Australia
Awarded by Ministry of Science and Technology of China
This research was supported by National Health and Medical Research Council of Australia Program Grants (1092642) (BHW, DL, KWH, LH, CR and DK) and Project Grant (1087355) (BHW, LH) and by the grants from the Ministry of Science and Technology of China (2016YFA0101300) (WJT, ZML).