Journal article

A Functional Immune System Is Required for the Systemic Genotoxic Effects of Localized Irradiation

Pavel N Lobachevsky, Jessica Ventura, Lina Giannakandropoulou, Helen Forrester, Jason S Palazzolo, Nicole M Haynes, Andrew W Stevenson, Christopher J Hall, Joel Mason, Gerasimos Pollakis, Ioannis S Pateras, Vassilis Gorgoulis, Georgia I Terzoudi, John A Hamilton, Carl N Sprung, Alexandros G Georgakilas, Olga A Martin



PURPOSE: Nontargeted effects of ionizing radiation, by which unirradiated cells and tissues are also damaged, are a relatively new paradigm in radiobiology. We recently reported radiation-induced abscopal effects (RIAEs) in normal tissues; namely, DNA damage, apoptosis, and activation of the local and systemic immune responses in C57BL6/J mice after irradiation of a small region of the body. High-dose-rate, synchrotron-generated broad beam or multiplanar x-ray microbeam radiation therapy was used with various field sizes and doses. This study explores components of the immune system involved in the generation of these abscopal effects. METHODS AND MATERIALS: The following mice with various i..

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Awarded by Australian National Health and Medical Research Council

Awarded by SARG-NKUA

Awarded by DAAD

Awarded by 2010 round of the priority driven Collaborative Cancer Research Scheme

Funding Acknowledgements

This research was supported by the Australian National Health and Medical Research Council grant #10275598.H.F. and C.N.S. were supported by the 2010 round of the priority driven Collaborative Cancer Research Scheme (grant #1002743), by the Australian Government Department of Health and Ageing, with the assistance of Cancer Australia, and by the Victorian Government's Operational Infrastructure Support Program. A.W.S. and C.J.H. were supported by the Australian Synchrotron. J.V. was supported by the Felix Meyer Scholarship in Obstetrics and Gynecology, University of Melbourne. V.G. and I.S.P. received financial support by SARG-NKUA grants #70/3/12128 and 70/3/8916. A.G.G., L.G., and G.P. acknowledge the support by DAAD grant #57339330.