Journal article
Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence
NY Fu, B Pal, Y Chen, FC Jackling, M Milevskiy, F Vaillant, BD Capaldo, F Guo, KH Liu, AC Rios, N Lim, AJ Kueh, DM Virshup, MJ Herold, HO Tucker, GK Smyth, GJ Lindeman, JE Visvader
Developmental Cell | CELL PRESS | Published : 2018
Abstract
Fu et al. show that the transcriptional repressor Foxp1 is crucial for governing the exit of mammary stem cells from quiescence. Moreover, Tspan8 was identified as a direct Foxp1 target that plays a functional role in regulating the stem cell state, and its deletion reversed the effects of Foxp1 loss.
Grants
Awarded by National Breast Cancer Foundation
Funding Acknowledgements
We thank A. Chen and P. Jamieson for expert assistance and M. Ritchie for discussions. We are grateful to the Animal, Genotyping, FACS, Imaging and Histology facilities at WEHI. This work was supported by the Australian National Health and Medical Research Council (NHMRC) grants #1016701, #1054618, #1100807, #1113133; NHMRC IRIISS; the Victorian state government through VCA funding and Operational Infrastructure Support; and the Australian Cancer Research Foundation. N.Y.F. and A.C.R. were supported by a National Breast Cancer Foundation/Cure Cancer Australia Fellowship; G.K.S., and G.J.L. by NHMRC Fellowships #1058892, #1078730; and J.E.V. by NHMRC Fellowships #1037230 and 1102742.