Journal article
Bipolar disorder and 1513A>C P2RX7 polymorphism frequency
C Gubert, R Andrejew, CE Jacintho Moritz, F Dietrich, MP Vasconcelos-Moreno, BTMQ dos Santos, A Fijtman, M Kauer-Sant'Anna, F Kapczinski, PV da Silva Magalhães, AMO Battastini
Neuroscience Letters | ELSEVIER IRELAND LTD | Published : 2019
Abstract
Although the etiology of Bipolar Disorder (BD) remains unknown, a strong genetic component to the pathogenesis and risk for this disorder has been widely hypothesized. Several risk genes for BD have been identified; of these, the purinergic P2 × 7 receptor (P2 × 7R) constitutes a pro-inflammatory receptor and a potential risk gene candidate. The purpose of the present study was to assess the frequency of the 1513 A > C P2RX7 polymorphism (rs3751143; Glu496Ala), which leads to receptor loss-of-function, in 154 BD patients versus 184 control subjects. The existence of a differential modulation of P2 × 7R was also analyzed in 22 euthymic BD patients, in comparison to 18 healthy controls. Our da..
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Awarded by Stanley Medical Research Institute
Funding Acknowledgements
This work was supported by grants from the National Science and Technology Institute for Translational Medicine (INCT-TM), Brazil (Project 573671/2008-7), INCT for excitotoxicity and neuroprotection (INCT-EN), Brazil (Project 465671/2014-4), Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil (Project No 303264/2013-6), and Fundo de Incentivo a Pesquisa - Hospital de Clinicas de Porto Alegre (FIPE-HCPA), Brazil. The funding agencies did not have any role in study design, data collection and analysis, the decision to publish, or manuscript preparation.