Journal article

Dysregulated IL-1-GM-CSF Axis in Acute Rheumatic Fever That Is Limited by Hydroxychloroquine

Man Lyang Kim, William J Martin, Gabriela Minigo, Joanne L Keeble, Alexandra L Garnham, Guido Pacini, Gordon K Smyth, Terence P Speed, Jonathan Carapetis, Ian P Wicks

CIRCULATION | LIPPINCOTT WILLIAMS & WILKINS | Published : 2018

Abstract

BACKGROUND: Acute rheumatic fever (ARF) and rheumatic heart disease are autoimmune consequences of group A streptococcus infection and remain major causes of cardiovascular morbidity and mortality around the world. Improved treatment has been stymied by gaps in understanding key steps in the immunopathogenesis of ARF and rheumatic heart disease. This study aimed to identify (1) effector T cell cytokine(s) that might be dysregulated in the autoimmune response of patients with ARF by group A streptococcus, and (2) an immunomodulatory agent that suppresses this response and could be clinically translatable to high-risk patients with ARF. METHODS: The immune response to group A streptococcus was..

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Grants

Awarded by H&L Hecht Trust, Perpetual Trustees


Awarded by Northern Territory Research and Innovation Board Research Grant


Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

This study was supported by the Walter and Eliza Hall Institute of Medical Research Indigenous Fund; H&L Hecht Trust, Perpetual Trustees (grant A11/00131); Northern Territory Research and Innovation Board Research Grant (ID 18-56); Reid Charitable Trusts; National Health and Medical Research Council of Australia (fellowship 1023407 to Professor Wicks, grant 0123462 to Professor Carapetis, fellowship 545245 to Dr Minigo, and program grant 1054618 to Professors Speed and Smyth); and Victorian State Government (Operational Infrastructure Grant).