Journal article

Centiloid scaling for quantification of brain amyloid with [F-18]flutemetamol using multiple processing methods

Mark R Battle, Lovena Chedumbarum Pillay, Val J Lowe, David Knopman, Bradley Kemp, Christopher C Rowe, Vincent Dore, Victor L Villemagne, Christopher J Buckley

EJNMMI RESEARCH | SPRINGEROPEN | Published : 2018

Abstract

INTRODUCTION: A standardised method for quantifying β-amyloid PET tracers would allow comparison across different tracers and different sites. The development of the Centiloid scale has aimed to achieve this, applying a common scale to better aid the diagnosis and prognosis of Alzheimer's disease (AD) and to monitor anti-amyloid therapeutic interventions. Here, we apply the Centiloid method to [18F]flutemetamol and [11C]PiB (PiB, Pittsburgh compound B) PET images and derive the scaling factor to express their binding in Centiloids. METHODS: Paired PiB and [18F]flutemetamol scans for 74 subjects, including 24 young healthy controls (37 ± 5 years), were analysed using the standard Centiloid me..

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