Associations of incidence of common adverse events (AEs) and survival outcomes in metastatic colorectal cancer (mCRC) patients (pts) treated with first line chemotherapy: Findings from 9,812 pts in the ARCAD database.
Danielle Angela Ferraro, John Raymond Zalcberg, Qian Shi, Jeffrey P Meyers, Matthew T Seymour, Leonard Saltz, Tim Maughan, Richard M Goldberg, Eric Van Cutsem, Volker Heinemann, Herbert Hurwitz, Alfredo Falcone, Eduardo Diaz-Rubio, Benoist Chibaudel, Charles S Fuchs, Rainer Porschen, Carsten Bokemeyer, Aimery De Gramont, Tim Price, Richard Adams
JOURNAL OF CLINICAL ONCOLOGY | AMER SOC CLINICAL ONCOLOGY | Published : 2018
617 Background: There is limited, often conflicting evidence about AE timing, severity or associations with outcomes with the use of cytotoxic agents in cancer treatment. We investigated the impact on overall survival (OS) and progression-free survival (PFS) of selected common AEs (neutropenia, diarrhea, nausea, vomiting, neuropathy) occurring in patients receiving first line oxaliplatin (Oxa)- and/or irinotecan(Iri)-based regimens for mCRC. Methods: The CTCAE grading scores of at least one AE of interest were available on 9812 pts treated with chemotherapy alone (median age 63; 62.4% male, 50.1% ECOG PS 0) from 17 1st-line randomized trials. Patients who also received biologics were exclud..View full abstract