Journal article

Cognitive and Functional Assessment of Psychosis Stratification Study (CoFAPSS): Rationale, Design, and Characteristics

Scott R Clark, K Oliver Schubert, Andrew T Olagunju, Ellen Alexandra Lyrtzis, Bernhard T Baune

FRONTIERS IN PSYCHIATRY | FRONTIERS MEDIA SA | Published : 2018

Abstract

Prediction of treatment response and illness trajectory in psychotic disorders including schizophrenia, bipolar affective disorder, schizoaffective disorder, and psychotic depression is difficult due to heterogeneity in presentation and outcome. Consequently, patients may receive prolonged ineffective treatments leading to functional decline, illness chronicity, and iatrogenic physical illness. One approach to addressing these problems is to stratify patients based on historical, clinical, and biological signatures. Such an approach has the potential to improve categorization resulting in better understanding of underlying mechanisms and earlier evidence-based treatment with reduced side eff..

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University of Melbourne Researchers