Focal stimulation of the sheep motor cortex with a chronically implanted minimally invasive electrode array mounted on an endovascular stent

Nicholas L Opie; Sam E John; Gil S Rind; Stephen M Ronayne; Yan T Wong; Giulia Gerboni; Peter E Yoo; Timothyj H Lovell; Theodore CM Scordas; Stefan L Wilson; Anthony Dornom; Thomas Vale; Terence J O'brien; David B Grayden; Clive N May; Thomasj Oxley

Journal article

Focal stimulation of the sheep motor cortex with a chronically implanted minimally invasive electrode array mounted on an endovascular stent

Nicholas L Opie, Sam E John, Gil S Rind, Stephen M Ronayne, Yan T Wong, Giulia Gerboni, Peter E Yoo, Timothyj H Lovell, Theodore CM Scordas, Stefan L Wilson, Anthony Dornom, Thomas Vale, Terence J O'brien, David B Grayden, Clive N May, Thomasj Oxley

NATURE BIOMEDICAL ENGINEERING | NATURE PUBLISHING GROUP | Published : 2018

DOI: 10.1038/s41551-018-0321-z

Abstract

Direct electrical stimulation of the brain can alleviate symptoms associated with Parkinson's disease, depression, epilepsy and other neurological disorders. However, access to the brain requires invasive procedures, such as the removal of a portion of the skull or the drilling of a burr hole. Also, electrode implantation into tissue can cause inflammatory tissue responses and brain trauma, and lead to device failure. Here, we report the development and application of a chronically implanted platinum electrode array mounted on a nitinol endovascular stent for the localized stimulation of cortical tissue from within a blood vessel. Following percutaneous angiographic implantation of the devic..

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University of Melbourne Researchers

Nicholas Opie Author Medicine - Royal Melbourne Hospital

Thomas Oxley Author Medicine - Royal Melbourne Hospital

Sam John Author Biomedical Engineering

Clive May Author Biochemistry and Pharmacology

Stephen Ronayne Author Medicine - Royal Melbourne Hospital

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Ian Potter Foundation Travel Grant

TARGETING THERAPEUTIC STIMULATION USING MINIMALLY INVASIVE NEUROMODULATION

Grants

Awarded by US Defense Advanced Research Projects Agency (DARPA) Microsystems Technology Office

Awarded by Office of Naval Research (ONR) Global

Awarded by National Health and Medical Research Council of Australia (NHMRC)

Funding Acknowledgements

This research was supported by the following grants: US Defense Advanced Research Projects Agency (DARPA) Microsystems Technology Office contract N66001-12-1-4045; Office of Naval Research (ONR) Global N62909-14-1-N020; National Health and Medical Research Council of Australia (NHMRC) Project Grant APP1062532. N.L.O. acknowledges the support of Westpac for the Bicentennial Research Fellowship.