Journal article

Brain structure and neurological and behavioural functioning in infants born preterm

Claire E Kelly, Deanne K Thompson, Jeanie LY Cheong, Jian Chen, Joy E Olsen, Abbey L Eeles, Jennifer M Walsh, Marc L Seal, Peter J Anderson, Lex W Doyle, Alicia J Spittle

DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY | WILEY | Published : 2019

Abstract

AIM: To examine: (1) relationships between brain structure, and concurrently assessed neurological and behavioural functioning, in infants born preterm at term-equivalent age (TEA; approximately 38-44wks); and (2) whether brain structure-function relationships differ between infants born very (24-29wks) and moderate-late (32-36wks) preterm. METHOD: A total of 257 infants (91 very preterm, 166 moderate-late preterm; 120 males, 137 females) had structural magnetic resonance imaging (MRI) and neurological and behavioural assessments (Prechtl's general movements assessment, Neonatal Intensive Care Unit Network Neurobehavioral Scale [NNNS] and Hammersmith Neonatal Neurological Examination [HNNE])..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by Australian National Health and Medical Research Council (Centre of Clinical Research Excellence)


Awarded by Australian National Health and Medical Research Council (Centre of Research Excellence)


Awarded by Australian National Health and Medical Research Council (Senior Research Fellowship)


Awarded by Australian National Health and Medical Research Council (Early Career Fellowship)


Awarded by Australian National Health and Medical Research Council (Career Development Fellowship)


Funding Acknowledgements

We gratefully acknowledge support from members of the Victorian Infant Brain Studies (VIBeS) group, the Developmental Imaging Group and Melbourne Children's MRI Centre at the Murdoch Children's Research Institute. We also thank the families who participated in the study. This work was supported in part by the Australian National Health and Medical Research Council (NHMRC; Project Grant ID 1028822 and 1024516; Centre of Clinical Research Excellence, Grant ID 546519; Centre of Research Excellence, Grant ID 1060733; Senior Research Fellowship, ID 1081288 to PJA; Early Career Fellowship, ID 1053787 to JLYC; ID 1053767 to AJS; ID 1012236 to DKT; Career Development Fellowship to AJS ID 1108714; to DKT ID 1085754), Murdoch Children's Research Institute Clinical Sciences Theme Grant, the Royal Children's Hospital, the Department of Paediatrics at the University of Melbourne, the Victorian Government Operational Infrastructure Support Program, and The Royal Children's Hospital Foundation.