Characterization of inhibitory failure in Multiple Sclerosis: Evidence of impaired conflict resolution

Abstract

INTRODUCTION: Inhibitory control deficits are frequently reported in Multiple Sclerosis (MS), although it is unclear whether these deficits represent a global or process-specific failure. Notably, most models of inhibitory control recognize at least two dissociable processes, the most consistent being: (a) the inhibition of a dominant response: response suppression, and (b) the inhibition of a dominant response and initiation of a nondominant response: executive control. This study aimed to ascertain the processes underlying inhibitory failure in MS. METHOD: Twenty-three MS patients and 25 healthy controls completed a battery of commonly used inhibitory tasks, with measures from each task en..