The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments.
Maria Cristina Morganti-Kossmann, Bridgette D Semple, Sarah C Hellewell, Nicole Bye, Jenna M Ziebell
Acta Neuropathol | Published : 2019
This review recounts the definitions and research evidence supporting the multifaceted roles of neuroinflammation in the injured brain following trauma. We summarise the literature fluctuating from the protective and detrimental properties that cytokines, leukocytes and glial cells play in the acute and chronic stages of TBI, including the intrinsic factors that influence cytokine responses and microglial functions relative to genetics, sex, and age. We elaborate on the pros and cons that cytokines, chemokines, and microglia play in brain repair, specifically neurogenesis, and how such conflicting roles may be harnessed therapeutically to sustain the survival of new neurons. With a brief rev..View full abstract