Journal article

Lithium during pregnancy and after delivery: a review.

Eline MP Poels, Hilmar H Bijma, Megan Galbally, Veerle Bergink

International Journal of Bipolar Disorders | Published : 2018


Lithium is an effective treatment in pregnancy and postpartum for the prevention of relapse in bipolar disorder. However, lithium has also been associated with risks during pregnancy for both the mother and the unborn child. Recent large studies have confirmed the association between first trimester lithium exposure and an increased risk of congenital malformations. Importantly, the risk estimates from these studies are lower than previously reported. Tapering of lithium during the first trimester could be considered but should be weighed against the risks of relapse. There seems to be no association between lithium use and pregnancy or delivery related outcomes, but more research is needed ..

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