Journal article
Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis
A Kamnaksh, N Puhakka, I Ali, G Smith, R Aniceto, J McCullough, S Das Gupta, XE Ndode-Ekane, R Brady, P Casillas-Espinosa, M Hudson, C Santana-Gomez, R Immonen, PAD Abreu, N Jones, S Shultz, RJ Staba, TJ O'Brien, D Agoston, A Pitkänen
Epilepsy Research | ELSEVIER SCIENCE BV | Published : 2019
Abstract
The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) is an international, multicenter, multidisciplinary study aimed at preventing epileptogenesis (EpiBioS4Rx: https://epibios.loni.usc.edu/). One of the study's major objectives is the discovery of diagnostic, prognostic, and predictive plasma protein and microRNA (miRNA) biomarkers that are sensitive, specific, and translatable to the human condition. Epilepsy due to structural brain abnormalities, secondary to neurological insults such as traumatic brain injury (TBI), currently represents ∼50% of all epilepsy cases. In the preclinical EpiBioS4Rx study, TBI was induced in adult male Sprague Dawley rats using a standar..
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Awarded by National Institute of Neurological Disorders and Stroke
Funding Acknowledgements
This work was supported by the National Institute of Neurological Disorders and Stroke (NINDS) Centers without Walls [grant number U54 NS100064].