Journal article
Assessing the role of the T-box transcription factor Eomes in B cell differentiation during either Th1 or Th2 cell-biased responses
L Cooper, L Hailes, A Sheikh, C Zaph, GT Belz, JR Groom, KL Good-Jacobson
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2018
Open access
Abstract
Successful T-dependent humoral responses require the production of antibody-secreting plasmablasts, as well as the formation of germinal centers which eventually form high-affinity B cell memory. The ability of B cells to differentiate into germinal center and plasma cells, as well as the ability to tailor responses to different pathogens, is driven by transcription factors. In T cells, the T-box transcription factors T-bet and Eomesodermin (Eomes) regulate effector and memory T cell differentiation, respectively. While T-bet has a critical role in regulating anti-viral B cell responses, a role for Eomes in B cells has yet to be described. We therefore investigated whether Eomes was required..
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Awarded by Australian Research Council
Funding Acknowledgements
This work was supported by a National Health and Medical Research Council (NHMRC; www.nhmrc.gov.au) project grant to KLG-J (1057707), and a NHMRC program grant to GTB (1054925). KLG-J is supported by an NHMRC Career Development Fellowship (1108066). GTB is supported by a NHMRC Senior Principal Research Fellowship (1135898) and JRG is supported by an Australian Research Council Future Fellowship (FT130100708) (www.arc.gov.au). This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. he funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.