Short-Term Environmental Stimulation Spatiotemporally Modulates Specific Serotonin Receptor Gene Expression and Behavioral Pharmacology in a Sexually Dimorphic Manner in Huntington's Disease Transgenic Mice
Michelle S Zajac, Thibault Renoir, Victoria M Perreau, Shanshan Li, Wendy Adams, Maarten van den Buuse, Anthony J Hannan
FRONTIERS IN MOLECULAR NEUROSCIENCE | FRONTIERS MEDIA SA | Published : 2018
Huntington's disease (HD) is a neurodegenerative disorder caused by a tandem repeat mutation encoding an expanded polyglutamine tract in the huntingtin protein, which leads to cognitive, psychiatric and motor dysfunction. Exposure to environmental enrichment (EE), which enhances levels of cognitive stimulation and physical activity, has therapeutic effects on cognitive, affective and motor function of transgenic HD mice. The present study investigated gene expression changes and behavioral pharmacology in male and female R6/1 transgenic HD mice at an early time-point in HD progression associated with onset of cognitive and affective abnormalities, following EE and exercise (wheel running) in..View full abstract
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This work was supported by an NHMRC Project Grant and ARC FT3 Future Fellowship to AH. TR is an NHMRC Dementia Fellow. AH is an NHMRC Principal Research Fellow.