Journal article
Positive airway pressure for sleep-disordered breathing in acute quadriplegia: A randomised controlled trial
DJ Berlowitz, R Schembri, M Graco, JM Ross, N Ayas, I Gordon, B Lee, A Graham, SV Cross, M McClelland, P Kennedy, P Thumbikat, C Bennett, A Townson, TJ Geraghty, S Pieri-Davies, R Singhal, K Marshall, D Short, A Nunn Show all
Thorax | BMJ PUBLISHING GROUP | Published : 2019
Abstract
Rationale Highly prevalent and severe sleep-disordered breathing caused by acute cervical spinal cord injury (quadriplegia) is associated with neurocognitive dysfunction and sleepiness and is likely to impair rehabilitation. Objective To determine whether 3 months of autotitrating CPAP would improve neurocognitive function, sleepiness, quality of life, anxiety and depression more than usual care in acute quadriplegia. Methods and measurements Multinational, randomised controlled trial (11 centres) from July 2009 to October 2015. The primary outcome was neurocognitive (attention and information processing as measure with the Paced Auditory Serial Addition Task). Daytime sleepiness (Karolinska..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The project was primarily funded by the Transport Accident Commission (Victoria, Australia) as an element of the Sleep Health in Quadriplegia research programme (DP158) and also supported by the National Health and Medical Research Council (Australia, APP1080020) and the Rick Hansen Foundation (Canada). Auto-setting continuous positive airway pressure devices were provided as in-kind support by ResMed (San Diego. USA).