Journal article

Positive airway pressure for sleep-disordered breathing in acute quadriplegia: a randomised controlled trial

David J Berlowitz, Rachel Schembri, Marnie Graco, Jacqueline M Ross, Najib Ayas, Ian Gordon, Bonne Lee, Allison Graham, Susan V Cross, Martin McClelland, Paul Kennedy, Pradeep Thumbikat, Cynthia Bennett, Andrea Townson, Timothy J Geraghty, Sue Pieri-Davies, Raj Singhal, Karen Marshall, Deborah Short, Andrew Nunn Show all



RATIONALE: Highly prevalent and severe sleep-disordered breathing caused by acute cervical spinal cord injury (quadriplegia) is associated with neurocognitive dysfunction and sleepiness and is likely to impair rehabilitation. OBJECTIVE: To determine whether 3 months of autotitrating CPAP would improve neurocognitive function, sleepiness, quality of life, anxiety and depression more than usual care in acute quadriplegia. METHODS AND MEASUREMENTS: Multinational, randomised controlled trial (11 centres) from July 2009 to October 2015. The primary outcome was neurocognitive (attention and information processing as measure with the Paced Auditory Serial Addition Task). Daytime sleepiness (Karolin..

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Awarded by Transport Accident Commission (Victoria, Australia)

Awarded by National Health and Medical Research Council (Australia)

Funding Acknowledgements

The project was primarily funded by the Transport Accident Commission (Victoria, Australia) as an element of the Sleep Health in Quadriplegia research programme (DP158) and also supported by the National Health and Medical Research Council (Australia, APP1080020) and the Rick Hansen Foundation (Canada). Auto-setting continuous positive airway pressure devices were provided as in-kind support by ResMed (San Diego. USA).