Journal article
CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline
Marc Suarez-Calvet, Anja Capell, Miguel Angel Araque Caballero, Estrella Morenas-Rodriguez, Katrin Fellerer, Nicolai Franzmeier, Gernot Kleinberger, Erden Eren, Yuetiva Deming, Laura Piccio, Celeste M Karch, Carlos Cruchaga, Katrina Paumier, Randall J Bateman, Anne M Fagan, John C Morris, Johannes Levin, Adrian Danek, Mathias Jucker, Colin L Masters Show all
EMBO MOLECULAR MEDICINE | WILEY | Published : 2018
Grants
Awarded by Deutsche Forschungsgemeinschaft (DFG)
Awarded by DFG
Awarded by Dominantly Inherited Alzheimer's Network (DIAN) - National Institute on Aging (NIA)
Awarded by HHS \ NIH \ National Institute on Aging (NIA)
Awarded by HHS \ NIH \ National Institute of Mental Health (NIMH) institutional training grant
Awarded by Fondazione Italiana Sclerosi Multipla (FISM)
Funding Acknowledgements
We would like to thank Tammie Benzinger, Krista Moulder, Peter Wang, Chengjie Xiong, Michael Donohue, Thomas Montine, Jihn K. Hsiao, Jacob Alexander and all the researchers in the DIAN and in the ADNI initiatives. We also thank Brigitte Nuscher and Nicole Exner for technical assistance and Jose Luis Molinuevo and Nicholas Ashton for critically reading the manuscript and helpful discussion. This work was supported by the Deutsche Forschungsgemeinschaft (DFG) within the framework of the Munich Cluster for Systems Neurology (EXC 1010 SyNergy), a DFG funded Koselleck Project (HA1737/16-1 to C.H.) and the FTD Biomarker Award. Data collection and sharing for this project were supported by The Dominantly Inherited Alzheimer's Network (DIAN, UF1AG032438) funded by the National Institute on Aging (NIA), the German Center for Neurodegenerative Diseases (DZNE), Raul Carrea Institute for Neurological Research (FLENI), Partial support by the Research and Development Grants for Dementia from Japan Agency for Medical Research and Development, AMED, and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI). This manuscript has been reviewed by DIAN study investigators for scientific content and consistency of data interpretation with previous DIAN study publications. We acknowledge the altruism of the participants and their families and contributions of the DIAN research and support staff at each of the participating sites for their contributions to this study. This work was also supported by grants from the HHS vertical bar NIH vertical bar National Institute on Aging (NIA) (R01AG044546, RF1AG053303, R01AG058501 and U01AG058922). YD is supported by an HHS vertical bar NIH vertical bar National Institute of Mental Health (NIMH) institutional training grant (T32MH014877). LP was supported by a grant from the Fondazione Italiana Sclerosi Multipla (FISM) (FISM 2017/R/20). EM was supported by a grant from the Ad-Hoc Committee for Young Neurologist (Spanish Society of Neurology) and Health Institute Carlos III (funding programme for the mobility of the researchers).