A case-control genome-wide association study of ADHD discovers a novel association with the tenascin R (TNR) gene

Ziarih Hawi; Hannah Yates; Ari Pinar; Aurina Arnatkeviciute; Beth Johnson; Janette Tong; Kealan Pugsley; Callum Dark; Marc Pauper; Marieke Klein; Helen S Heussler; Harriet Hiscock; Alex Fornito; Jeggan Tiego; Amy Finlay; Alasdair Vance; Michael Gill; Lindsey Kent; Mark A Bellgrove

Journal article

A case-control genome-wide association study of ADHD discovers a novel association with the tenascin R (TNR) gene

Ziarih Hawi, Hannah Yates, Ari Pinar, Aurina Arnatkeviciute, Beth Johnson, Janette Tong, Kealan Pugsley, Callum Dark, Marc Pauper, Marieke Klein, Helen S Heussler, Harriet Hiscock, Alex Fornito, Jeggan Tiego, Amy Finlay, Alasdair Vance, Michael Gill, Lindsey Kent, Mark A Bellgrove

TRANSLATIONAL PSYCHIATRY | NATURE PUBLISHING GROUP | Published : 2018

DOI: 10.1038/s41398-018-0329-x

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Abstract

It is well-established that there is a strong genetic contribution to the aetiology of attention deficit hyperactivity disorder (ADHD). Here, we employed a hypothesis-free genome-wide association study (GWAS) design in a sample of 480 clinical childhood ADHD cases and 1208 controls to search for novel genetic risk loci for ADHD. DNA was genotyped using Illumina's Human Infinium PsychArray-24v1.2., and the data were subsequently imputed to the 1000 Genomes reference panel. Rigorous quality control and pruning of genotypes at both individual subject and single nucleotide polymorphism (SNP) levels was performed. Polygenic risk score (PGRS) analysis revealed that ADHD case-control status was exp..

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University of Melbourne Researchers

Harriet Hiscock Author Paediatrics Royal Children's Hospital

Alasdair Vance Author Paediatrics Royal Children's Hospital

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This work has been supported by Project Grant funding from the National Health and Medical Research Council (NHMRC) of Australia to Z.H. (1006573, 1002458 and 1065677) and M.A.B. (569636, 1065677, 1045354, 1002458 and 1006573).