Quantitative Proteomics by SWATH-MS Suggest an Association Between Circulating Exosomes and Maternal Metabolic Changes in Gestational Diabetes Mellitus

Nanthini Jayabalan; Andrew Lai; Soumyalekshmi Nair; Dominic Guanzon; Katherin Scholz-Romero; Carlos Palma; Harold David McIntyre; Martha Lappas; Carlos Salomon

Journal article

Quantitative Proteomics by SWATH-MS Suggest an Association Between Circulating Exosomes and Maternal Metabolic Changes in Gestational Diabetes Mellitus

Nanthini Jayabalan, Andrew Lai, Soumyalekshmi Nair, Dominic Guanzon, Katherin Scholz-Romero, Carlos Palma, Harold David McIntyre, Martha Lappas, Carlos Salomon

PROTEOMICS | WILEY | Published : 2019

DOI: 10.1002/pmic.201800164

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Abstract

Several factors including placental hormones (PH) released from the human placenta have been associated with the development of insulin resistance and gestational diabetes mellitus (GDM). However, circulating levels of PH does not correlate well with maternal insulin sensitivity across gestation, suggesting that other, previously unrecognized, mechanisms may be involved. The levels of circulating exosomes are higher in GDM compared to normal. GDM derived exosomes produce greater release of pro-inflammatory cytokines from endothelial cells compared to exosomes from normal, suggesting that their contents may differ compared to normal pregnancies. Using a quantitative, information-independent a..

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University of Melbourne Researchers

Martha Lappas Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

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Awarded by National Health and Medical Research Council (NHMRC)

Awarded by FondoNacional de Desarrollo Cientifico y Tecnologico (FONDECYT)

Awarded by Career Development Fellowship from the National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

The following are gratefully acknowledged: the clinical research midwives Genevieve Christophers, Gabrielle Pell, and Rachel Murdoch for sample collection; and the Obstetrics and Midwifery staff of the Mercy Hospital for Women for their co-operation. This study was supported by Lions Medical Research Foundation, The University of Queensland, Faculty of Medicine M+BS Emerging Leaders Medical Research Grant, National Health and Medical Research Council (NHMRC; 1114013), Diabetes Australia, and FondoNacional de Desarrollo Cientifico y Tecnologico (FONDECYT 1170809). Associate Professor M.L. is supported by a Career Development Fellowship from the National Health and Medical Research Council (NHMRC; grant no. 1047025) and a Research Fellowship from The University of Melbourne. N.J. holds a Scholarship from the Public Service Department of the Malaysian Government.