Mid-calf skeletal muscle density and its associations with physical activity, bone health and incident 12-month falls in older adults: The Healthy Ageing Initiative
David Scott, Jonas Johansson, Lachlan B McMillan, Peter R Ebeling, Anna Nordstrom, Peter Nordstrom
BONE | ELSEVIER SCIENCE INC | Published : 2019
BACKGROUND: Lower skeletal muscle density, indicating greater infiltration of adipose tissue into muscles, is associated with higher fracture risk in older adults. We aimed to determine whether mid-calf muscle density is associated with falls risk and bone health in community-dwelling older adults. METHODS: 2214 community-dwelling men and women who participated in the Healthy Ageing Initiative (Sweden) study at age 70 were included in this analysis. Mid-calf muscle density (mg/cm3) at the proximal tibia, and volumetric bone mineral density (vBMD) and architecture at the distal and proximal tibia and radius, were assessed by peripheral quantitative computed tomography. Whole-body lean and fat..View full abstract
Awarded by Swedish Research Council
Awarded by NHMRC RD Wright Biomedical Career Development Fellowship
This study was funded by the Swedish Research Council (grant number 2011-2976). DS is supported by a NHMRC RD Wright Biomedical Career Development Fellowship (GNT1123014). LBM is supported by an Australian Postgraduate Award.