Journal article
Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer
Y Lu, SS Kweon, C Tanikawa, WH Jia, YB Xiang, Q Cai, C Zeng, SL Schmit, A Shin, K Matsuo, SH Jee, DH Kim, J Kim, W Wen, J Shi, X Guo, B Li, N Wang, B Zhang, X Li Show all
Gastroenterology | Published : 2019
Abstract
Background & Aims: Genome-wide association studies (GWASs) have associated approximately 50 loci with risk of colorectal cancer (CRC)—nearly one third of these loci were initially associated with CRC in studies conducted in East Asian populations. We conducted a GWAS of East Asians to identify CRC risk loci and evaluate the generalizability of findings from GWASs of European populations to Asian populations. Methods: We analyzed genetic data from 22,775 patients with CRC (cases) and 47,731 individuals without cancer (controls) from 14 studies in the Asia Colorectal Cancer Consortium. First, we performed a meta-analysis of 7 GWASs (10,625 cases and 34,595 controls) and identified 46,554 promi..
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Awarded by Groupement des Entreprises Françaises dans la lutte contre le Cancer
Funding Acknowledgements
The work at Vanderbilt University Medical Center was supported by US National Institutes of Health (NIH) grants R01CA188214, R37CA070867, R01CA124558, R01CA158473, and R01CA148667, as well as Anne Potter Wilson Chair funds from the Vanderbilt University School of Medicine. Sample preparation and genotyping assays at Vanderbilt University were conducted at the Survey and Biospecimen Shared Resources and Vanderbilt Microarray Shared Resource, which are supported in part by the Vanderbilt-Ingram Cancer Center (P30CA068485). Imputation and statistical analyses were performed on servers maintained by the Advanced Computing Center for Research and Education at Vanderbilt University.