Journal article

Varicella vaccine effectiveness over 10 years in Australia; moderate protection from 1-dose program

Helen E Quinn, Heather F Gidding, Helen S Marshall, Robert Booy, Elizabeth J Elliott, Peter Richmond, Nigel Crawford, Peter B McIntyrean, Kristine K Macartney, C Blyth, P Britton, J Buttery, JE Clark, J Connell, R Dale, M Deverell, S Dougherty, C Finucane, M Gibson, M Gold Show all

JOURNAL OF INFECTION | W B SAUNDERS CO LTD | Published : 2019

Abstract

OBJECTIVES: To examine the impact of Australia's single dose infant varicella vaccination program, we assessed single dose varicella vaccine effectiveness (VE) in preventing hospitalised disease using two methods. METHODS: Clinically confirmed varicella cases from the Paediatric Active Enhanced Disease Surveillance (PAEDS) sentinel network were age-matched to 20 controls obtained from the Australian Immunisation Register. Conditional logistic regression models were used to estimate VE and compared with estimates obtained using our second approach. RESULTS: There were 78 hospitalised varicella cases during the post vaccine introduction period from January 2008 to December 2015, who were eligi..

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Grants

Awarded by NHMRC Career Development Fellowships


Awarded by NHMRC


Funding Acknowledgements

We thank Brynley Hull (NCIRS) for the provision of AIR coverage information. PAEDS is supported by the Australian Government Department of Health and Departments of Health in participating jurisdictions (NSW, Victoria, South Australia, Western Australia and Queensland). HM and HG have been awarded NHMRC Career Development Fellowships (2011-2014 and 2015-2018 APP1084951). EE and RB have been awarded NHMRC Practitioner Fellowships (2012-2016 APP1135959 and 2016-2020 APP1110891, respectively).