mRNA expression of the P5 ATPase ATP13A4 is increased in Broca's Area from subjects with schizophrenia.
Andrew Gibbons, Laura Bell, Madhara Udawela, Brian Dean
World Journal of Biological Psychiatry | Taylor & Francis | Published : 2018
OBJECTIVE: ATPase Type 13A4 (ATP13A4) is a cation-transporting, P5-type ATPase that has been implicated in neurodevelopmental disorders. Our recent microarray study reported a significant increase in ATP13A4 mRNA levels in Brodmann's Area (BA) 9 in subjects with schizophrenia compared to controls. Following this discovery we have sought to determine whether ATP13A4 expression was altered in other regions of the CNS that are affected in schizophrenia. METHODS: Quantitative PCR was used to measure the levels of ATP13A4 in BA 44 and BA 8, collected post-mortem, from 30 subjects with schizophrenia and 30 non-psychiatric control subjects. To address the potential confound of antipsychotic medic..View full abstract