Noncoding RNAs regulating cardiac muscle mass
Glenn D Wadley, Severine Lamon, Sarah E Alexander, Julie R McMullen, Bianca C Bernardo
Journal of Applied Physiology | AMER PHYSIOLOGICAL SOC | Published : 2019
Non-coding RNAs, including miRNAs, lncRNAs and circRNAs play roles in the development and homeostasis of nearly every tissue of the body, including the regulation of processes underlying heart growth. Cardiac hypertrophy can be classified as either physiological (beneficial heart growth) or pathological (detrimental heart growth), the latter which results in impaired cardiac function, heart failure and is predictive of a higher incidence of death due to cardiovascular disease. Several miRNAs have a functional role in exercise-induced cardiac hypertrophy, whilst both miRNAs and lncRNAs are heavily involved in pathological heart growth and heart failure. The latter have the potential to act as..View full abstract
Awarded by National Health and Medical Research Council
J. R. McMullen is supported by a National Health and Medical Research Council Senior Research Fellowship Grant 1078985, and B. C. Bernardo is supported by an Alice Baker and Eleanor Shaw Fellowship (The Baker Foundation, Melbourne, Australia).