Journal article

Prospective validation of the NCI Breast Cancer Risk Assessment Tool (Gail Model) on 40,000 Australian women

Carolyn Nickson, Pietro Procopio, Louiza S Velentzis, Sarah Carr, Lisa Devereux, Gregory Bruce Mann, Paul James, Grant Lee, Cameron Wellard, Ian Campbell

BREAST CANCER RESEARCH | BMC | Published : 2018

Abstract

BACKGROUND: There is a growing interest in delivering more personalised, risk-based breast cancer screening protocols. This requires population-level validation of practical models that can stratify women into breast cancer risk groups. Few studies have evaluated the Gail model (NCI Breast Cancer Risk Assessment Tool) in a population screening setting; we validated this tool in a large, screened population. METHODS: We used data from 40,158 women aged 50-69 years (via the lifepool cohort) participating in Australia's BreastScreen programme. We investigated the association between Gail scores and future invasive breast cancer, comparing observed and expected outcomes by Gail score ranked grou..

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Grants

Awarded by Cancer Australia


Awarded by National Breast Cancer Foundation Collaborative Cancer Research Grant


Awarded by National Breast Cancer Foundation Infrastructure Grant


Funding Acknowledgements

This work was supported by Cancer Australia (pdCCRS grant 1084963), National Breast Cancer Foundation Collaborative Cancer Research Grant (grant number CG_08_02), and National Breast Cancer Foundation Infrastructure Grant (grant number IF-15-004). The funder had no role in the design of the study, the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication.