Journal article
Targeted Graphene Oxide Networks: Cytotoxicity and Synergy with Anticancer Agents
E Bidram, A Sulistio, HJ Cho, A Amini, T Harris, A Zarrabi, G Qiao, A Stewart, DE Dunstan
ACS Applied Materials and Interfaces | AMER CHEMICAL SOC | Published : 2018
Abstract
An effective strategy to inhibit endocytosis in cancer cells is presented where modified net-type graphene oxide (GO) sheets, bound with multiple cell surface receptors, are introduced and synthesized as novel anticancer agents. The results suggest that the binding connects GO sheets with neighboring lipid rafts, neutralizes endocytosis, and causes metabolic deprivation. As a result, tumor cell survival and proliferation are reduced. Live cell confocal microscopy imaging reveals that GO-PEGFA (folate-PEGylated GO) (PEG, polyethylene glycol) is internalized by tumor cells, while GO-PEGRGD (tripeptide Arg-Gly-Asp PEGylated GO) associates with the external cell membrane (not internalized). In v..
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Funding Acknowledgements
Financial support from the University of Melbourne is greatly acknowledged. The support from the University of Isfahan and Australian College of Kuwait for funding No. IRC-2017-18-OE-ME-PR01 and PR02 are also acknowledged.