Journal article

Brain-Derived Neurotrophic Factor in Central Nervous System Myelination: A New Mechanism to Promote Myelin Plasticity and Repair

Jessica L Fletcher, Simon S Murray, Junhua Xiao



Brain-derived neurotrophic factor (BDNF) plays vitally important roles in neural development and plasticity in both health and disease. Recent studies using mutant mice to selectively manipulate BDNF signalling in desired cell types, in combination with animal models of demyelinating disease, have demonstrated that BDNF not only potentiates normal central nervous system myelination in development but enhances recovery after myelin injury. However, the precise mechanisms by which BDNF enhances myelination in development and repair are unclear. Here, we review some of the recent progress made in understanding the influence BDNF exerts upon the myelinating process during development and after i..

View full abstract

University of Melbourne Researchers


Awarded by Australian Research Council

Awarded by Australian National Health and Medical Research Council

Awarded by Multiple Sclerosis Research Program

Funding Acknowledgements

J.L.F. was supported by a Melbourne Neuroscience Institute Fellowship (2018). This work was funded by an Australian Research Council Discovery Project Grant (#DP180102397) awarded to J.X, and an Australian National Health and Medical Research Council Project Grant (#APP1105108) awarded to S.S.M This work was supported by the Assistant Secretary of Defense for Health Affairs, endorsed by the Department of Defense, USA, through the Multiple Sclerosis Research Program W81XWH-17-MSRP-IIRA under Award No. MS170031 to J.X. Opinions, interpretations, conclusions and recommendations are those of the authors and are not necessarily endorsed by the Assistant Secretary of Defense for Health Affairs or Department of Defense (USA).