An analysis of multiple biomarkers to better predict prostate cancer metastasis and death after radical prostatectomy.
Alison Yan Zhang, Karen Chiam, Ygal Haupt, Stephen B Fox, Simone Birch, Wayne Tilley, Lisa Butler, Karen E Knudsen, Christopher Cornstock, Krishan Rasiah, Judith Grogan, Kate Lynette Mahon, Tina Bianco-Miotto, Maret Bohm, Susan M Henshall, Warick Delprado, Phillip Stricker, Lisa Horvath, James Kench
JOURNAL OF CLINICAL ONCOLOGY | AMER SOC CLINICAL ONCOLOGY | Published : 2018
54 Background: Identification of potentially lethal disease at the time of diagnosis with localized prostate cancer (PCa) remains a significant clinical issue despite a plethora of candidate biomarkers. This study evaluates a range of biomarkers previously associated with biochemical relapse (BR) in localized PCa to determine whether a combined expression model can improve detection of clinically significant cases. Methods: The Australian PCa Research Centre NSW has completed 23 studies of molecular biomarkers associated with BR in a well-described localized PCa cohort (n=324, median followup 16 years). 12 studies were excluded due to missing data. Each biomarker was analyzed as a marker fo..View full abstract