Cytokine biomarkers for the diagnosis of tuberculosis infection and disease in adults in a low prevalence setting

V Clifford; M Tebruegge; C Zufferey; S Germano; B Forbes; L Cosentino; E Matchett; E McBryde; D Eisen; R Robins-Browne; A Street; J Denholm; N Curtis

Journal article

Cytokine biomarkers for the diagnosis of tuberculosis infection and disease in adults in a low prevalence setting

V Clifford, M Tebruegge, C Zufferey, S Germano, B Forbes, L Cosentino, E Matchett, E McBryde, D Eisen, R Robins-Browne, A Street, J Denholm, N Curtis

Tuberculosis | CHURCHILL LIVINGSTONE | Published : 2019

DOI: 10.1016/j.tube.2018.08.011

Abstract

Objective: Accurate and timely diagnosis of tuberculosis (TB) is essential to control the global pandemic. Currently available immunodiagnostic tests cannot discriminate between latent tuberculosis infection (LTBI) and active tuberculosis. This study aimed to determine whether candidate mycobacterial antigen-stimulated cytokine biomarkers can discriminate between TB-uninfected and TB-infected adults, and additionally between LTBI and active TB disease. Methods: 193 adults were recruited, and categorised into four unambiguous diagnostic groups: microbiologically-proven active TB, LTBI, sick controls (non-TB lower respiratory tract infections) and healthy controls. Whole blood assays were used..

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University of Melbourne Researchers

Vanessa Clifford Author

Roy Robins-Browne Author

Justin Denholm Author

Nigel Curtis Author

Grants

Funding Acknowledgements

This study was supported by a grant from the John Burge trust. MT was supported by a Clinical Lectureship provided by the U.K. National Institute for Health Research.