Journal article

Legionella protection and vaccination mediated by Mucosal Associated Invariant T (MAIT) cells

Huimeng Wang, Criselle D’Souza, Xin Yi Lim, Lyudmila Kostenko, Troi Pediongco, Sidonia BG Eckle, Bronwyn Meehan, Nancy Wang, Shihan Li, Ligong Liu, Jeffrey YW Mak, David Fairlie, Yoichiro Iwakura, Jennifer Gunnersen, Andrew Stent, Jamie Rossjohn, Glen Westall, Lars Kjer-Nielsen, Richard Strugnell, James McCluskey Show all

Published : 2017

Abstract

Abstract Mucosal associated invariant T (MAIT) cells recognize conserved microbial metabolites from riboflavin synthesis. Striking evolutionary conservation and pulmonary abundance implicate them in antibacterial host defense, yet their roles in protection against clinically significant pathogens are unknown. Murine Legionella infection induced MR1-dependent MAIT cell activation and rapid pulmonary accumulation of MAIT cells associated with immune protection detectable in fully immunocompetent host animals. MAIT cell protection was more evident in mice lacking CD4+ cells, whilst profoundly immunodeficient RAG2 −/− γC −/− mice were substantially rescued from uniformly lethal Legionella infect..

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