Decoding transcriptomic intra-tumour heterogeneity to guide personalised medicine in ovarian cancer
Tuan Zea Tan, Valerie Heong, Jieru Ye, Diana Lim, Jeffrey Low, Mahesh Choolani, Clare Scott, David Shao Peng Tan, Ruby Yun-Ju Huang
JOURNAL OF PATHOLOGY | WILEY | Published : 2019
The evaluation of intra-tumour heterogeneity (ITH) from a transcriptomic point of view is limited. Single-cell cancer studies reveal significant genomic and transcriptomic ITH within a tumour and it is no longer adequate to employ single-subtype assignment as this does not acknowledge the ITH that exists. Molecular assessment of subtype heterogeneity (MASH) was developed to comprehensively report on the composition of all transcriptomic subtypes within a tumour lesion. Using MASH on 3431 ovarian cancer samples, correlation and association analyses with survival, metastasis and clinical outcomes were performed to assess the impact of subtype composition as a surrogate for ITH. The association..View full abstract
This work was supported by National Research Foundation (NRF) Singapore and the Singapore Ministry of Health under its Research Centres of Excellence initiative to RYH; National Medical Research Council (NMRC) under its Centre Grant scheme to National University Cancer Institute (NCIS) to RYH.