Journal article

Neuropathology as a consequence of neonatal ventilation in premature growth-restricted lambs

Atul Malhotra, Margie Castillo-Melendez, Beth J Allison, Amy E Sutherland, Ilias Nitsos, Yen Pham, Anna K Alves de Alencar Rocha, Michael C Fahey, Graeme R Polease, Graham Jenkin, Suzanne L Miller

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2018

Abstract

Fetal growth restriction (FGR) and prematurity are associated with high risk of brain injury and long-term neurological deficits. FGR infants born preterm are commonly exposed to mechanical ventilation, but it is not known whether ventilation differentially induces brain pathology in FGR infants compared with appropriate for gestational age (AGA) infants. We investigated markers of neuropathology in moderate- to late-preterm FGR lambs, compared with AGA lambs, delivered by caesarean birth and ventilated under standard neonatal conditions for 24 h. FGR was induced by single umbilical artery ligation in fetal sheep at 88-day gestation (term, 150 days). At 125-day gestation, FGR and AGA lambs w..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by Cerebral Palsy Alliance Research Grant


Funding Acknowledgements

This study was supported by a National Health and Medical Research Council (NHMRC) Project Grant (APP1083520), Cerebral Palsy Alliance Research Grant (PG0414), Royal Australasian College of Physicians Research Scholarship (to A. Malhotra), NHMRC Career Development Fellowship (to G. R. Polglase), Australian Research Council Future Fellowship (to S. L. Miller), and Victorian Government's Operational Infrastructure Program.