Journal article

Age at menarche and childhood body mass index as predictors of cardio-metabolic risk in young adulthood: A prospective cohort study

Chi Le-Ha, Lawrence J Beilin, Sally Burrows, Rae-Chi Huang, Martha Hickey, Trevor A Mori, Roger J Hart

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2018

Abstract

OBJECTIVE: This study aimed to examine the association between age at menarche and a range of cardiovascular disease (CVD) risk factors at 17 and 20 years of age, and whether this was influenced by childhood body mass index (BMI). METHODS: Of the 1413 girls born in the Western Australian Pregnancy Cohort (Raine) Study, 846 had age at menarche recorded. Subsequently 557 underwent metabolic assessment at 17 years and 541 at 20 years. Associations between age at menarche and cardiovascular risk factors, and being in a high-risk metabolic cluster at 17 and 20 years, or having the metabolic syndrome at 20 years, were investigated by linear mixed effects and logistic regressions, respectively. RES..

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Grants

Awarded by NHMRC


Funding Acknowledgements

This work was supported by Core funding of the Raine Study is contributed by the University of Western Australia (UWA), the Telethon Kids Institute, the Raine Medical Research Foundation, the UWA Faculty of Medicine, Dentistry and Health Science, the Women and Infants Research Foundation, Curtin University, Edith Cowan University, Murdoch University, and the University of Notre Dame Australia. The Raine Study has long-term support from the National Health and Medical Research Council of Australia. The data collection of the 17 year follow-up of the Raine Study was funded by an NHMRC grant (Beilin et al, ID 403981). Rae-Chi Huang and Trevor A Mori are supported by NHMRC fellowships 1053384 and 1042255, respectively. Martha Hickey is supported by NHMRC Practitioner Fellowship APP1058935. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.