Journal article

Change in Emotional and Theory of Mind Processing in Borderline Personality Disorder A Pilot Study

Ueli Kramer, Stephane Kolly, Pauline Maillard, Antonio Pascual-Leone, Andrea C Samson, Ruth Schmitt, Adriano Bernini, Gilles Allenbach, Patrick Charbon, Yves de Roten, Philippe Conus, Jean-Nicolas Despland, Bogdan Draganski

JOURNAL OF NERVOUS AND MENTAL DISEASE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2018

Abstract

Changes in emotional processing (EP) and in theory of mind (TOM) are central across treatment approaches for patients with borderline personality disorder (BPD). Although the assessment of EP relies on the observation of a patient's self-criticism in a two-chair dialogue, an individual's TOM assessments is made based on responses to humorous stimuli based on false beliefs. For this pilot study, we assessed eight patients with BPD before and after a 3-month-long psychiatric treatment, using functional magnetic resonance imaging and behavioral tasks. We observed arousal increase within the session of the two-chair dialogue (d = 0.36), paralleled by arousal decrease between sessions (d = 0.80)...

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Grants

Awarded by Swiss National Science Foundation (NCCR Synapsy)


Funding Acknowledgements

B.D. is supported by the Swiss National Science Foundation (NCCR Synapsy, project grant no. 32003B_159780) and Foundation Synapsis. LREN is very grateful to the Roger De Spoelberch and Partridge Foundations for their generous financial support. The authors are very grateful for the generous support by Prof Sabine C. Herpertz, University of Heidelberg, and the Department of Psychiatry-Lausanne University Hospital (CHUV), University of Lausanne.