Interaction of Glutathione S-Transferase M1, T1, and P1 Genes With Early Life Tobacco Smoke Exposure on Lung Function in Adolescents
Xin Dai, Shyamali C Dharmage, Gayan Bowatte, Nilakshi T Waidyatillake, Jennifer L Perret, Jennie Hui, Bircan Erbas, Michael J Abramson, Adrian J Lowe, John A Burgess, Cecilie Svanes, Caroline J Lodge
CHEST | ELSEVIER | Published : 2019
BACKGROUND: Glutathione S-transferase (GST) genes are involved in the management of oxidative stress in the lungs. We aimed to determine whether they modify the associations between early life smoke exposure and adverse lung health outcomes. METHODS: The Melbourne Atopy Cohort study (a high-risk birth cohort) enrolled 620 children and followed them prospectively from birth. We recorded perinatal tobacco smoke exposure, asthma, and lung function at 12 (59%) and 18 years (66%) and genotyped for GSTM1, GSTT1, and GSTP1 (69%). RESULTS: GST genotypes were found to interact with tobacco smoke exposure on lung function outcomes (P interaction ≤ .05). Only among children with GSTT1 null genotypes wa..View full abstract
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This study was funded by the National Health and Medical Research Council of Australia, VicHealth, The Asthma Foundation and Nestle Australia. X. D., S. C. D., G. B., J. L. P., A. J. L., and C. J. L. are funded by the National Health and Medical Research Council of Australia; and G. B. and J. L. P. were funded by the Centre for Air Quality & Health Research and Evaluation of Australia in 20162017, and are funded by the National Health and Medical Research Council of Australia in 2018.