Harnessing stem cells and biomaterials to promote neural repair
KF Bruggeman, N Moriarty, E Dowd, DR Nisbet, CL Parish
BRITISH JOURNAL OF PHARMACOLOGY | WILEY | Published : 2019
With the limited capacity for self-repair in the adult CNS, efforts to stimulate quiescent stem cell populations within discrete brain regions, as well as harness the potential of stem cell transplants, offer significant hope for neural repair. These new cells are capable of providing trophic cues to support residual host populations and/or replace those cells lost to the primary insult. However, issues with low-level adult neurogenesis, cell survival, directed differentiation and inadequate reinnervation of host tissue have impeded the full potential of these therapeutic approaches and their clinical advancement. Biomaterials offer novel approaches to stimulate endogenous neurogenesis, as w..View full abstract
C.L.P. was supported by a Viertel Charitable foundation senior research fellowship, Australia.