Identification and characterization of an M cell marker in nasopharynx- and oropharynx-associated lymphoid tissue of sheep
Vijay Kumar Saxena, Alejandra Diaz, Jean-Pierre Y Scheerlinck
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | ELSEVIER | Published : 2019
M cells play a pivotal role in the induction of immune responses within the mucosa-associated lymphoid tissues. M cells exist principally in the follicle-associated epithelium (FAE) of the isolated solitary lymphoid follicles as well as in the lymphoid follicles of nasopharynx-associated lymphoid tissue and gut associated lymphoid tissue (GALT). Through lymphatic cannulation it is possible to investigate local immune responses induced following nasal Ag delivery in sheep. Hence, identifying sheep M cell markers would allow the targeting of M cells to offset the problem of trans-epithelial Ag delivery associated with inducing mucosal immunity. Sheep cDNA from the tonsils of the oropharynx and..View full abstract
VKS is thankful to Department of Biotechnology, Government of India for providing the financial support through the Indo-Australia Career Boosting Gold Fellowship. AD was the recipient of an Endeavour Research Fellowship from the Australian Government.