Journal article

Identification and characterization of an M cell marker in nasopharynx- and oropharynx-associated lymphoid tissue of sheep

Vijay Kumar Saxena, Alejandra Diaz, Jean-Pierre Y Scheerlinck

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | ELSEVIER | Published : 2019

Abstract

M cells play a pivotal role in the induction of immune responses within the mucosa-associated lymphoid tissues. M cells exist principally in the follicle-associated epithelium (FAE) of the isolated solitary lymphoid follicles as well as in the lymphoid follicles of nasopharynx-associated lymphoid tissue and gut associated lymphoid tissue (GALT). Through lymphatic cannulation it is possible to investigate local immune responses induced following nasal Ag delivery in sheep. Hence, identifying sheep M cell markers would allow the targeting of M cells to offset the problem of trans-epithelial Ag delivery associated with inducing mucosal immunity. Sheep cDNA from the tonsils of the oropharynx and..

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Grants

Funding Acknowledgements

VKS is thankful to Department of Biotechnology, Government of India for providing the financial support through the Indo-Australia Career Boosting Gold Fellowship. AD was the recipient of an Endeavour Research Fellowship from the Australian Government.