Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy
Jonathan P Bernardini, Jason M Brouwer, Iris KL Tan, Jarrod J Sandow, Shuai Huang, Che A Stafford, Aleksandra Bankovacki, Christopher D Riffkin, Ahmad Z Wardak, Peter E Czabotar, Michael Lazarou, Grant Dewson
The EMBO Journal | WILEY | Published : 2019
Awarded by National Health and Medical Research Council
Awarded by Australian Research Council
Awarded by Victorian State Government
We thank B. Reljic and M. Ryan for providing the VDAC2 antibody, D.C.S. Huang and D. Segal for cell lines and K. Scicluna for assistance with the manuscript. We thank Dario Altieri (Wistar Institute Cancer Center, Philadelphia) for the mitochondrial Hsp90 inhibitor GTPP. J.P.B. is supported by an Australian Government Research Training Program Scholarship and a Cancer Therapeutics CRC PhD Top Up Scholarship. M.L. is supported by the National Health and Medical Research Council (GNT1106471), and a fellowship from the Australian Research Council (FT160100063). P.E.C is supported by a fellowship from the National Health and Medical research Council (1079700). This work was supported by grants from the National Health and Medical Research Council (1078924), a fellowship from the Australian Research Council (FT100100791 to G.D.) and operational infrastructure grants through the Australian Government IRISS and the Victorian State Government OIS 9000220.