Journal article

Electroanatomical Remodeling of the Atria in Obesity Impact of Adjacent Epicardial Fat

Rajiv Mahajan, Adam Nelson, Rajeev K Pathak, Melissa E Middeldorp, Christopher X Wong, Darragh J Twomey, Angelo Carbone, Karen Teo, Thomas Agbaedeng, Dominik Linz, Joris R de Groot, Jonathan M Kalman, Dennis H Lau, Prashanthan Sanders

JACC Clinical Electrophysiology | ELSEVIER | Published : 2018

Abstract

OBJECTIVES: The aims of the study were to characterize: 1) electrical and electroanatomical remodeling in patients with atrial fibrillation (AF) with obesity; and 2) the impact of epicardial fat depots on adjacent atrial tissue. BACKGROUND: Obesity is associated with an increased risk of AF. METHODS: A total of 115 patients with AF who underwent AF ablation were screened. After exclusion, 26 patients were divided into 2 groups (obese: body mass index [BMI] ≥27 kg/m2 and reference: BMI <27 kg/m2). They underwent cardiac magnetic resonance (CMR) imaging and electroanatomic mapping of the left atrium (LA) in sinus rhythm before AF ablation. Atrial and ventricular epicardial adipose tissue (EAT)..

View full abstract

Grants

Funding Acknowledgements

This study was supported by funds from the Centre of Heart Rhythm Disorders at the University of Adelaide. This study was presented at the Annual Scientific Sessions of the Heart Rhythm Society, May 2015, Boston, Massachusetts and was awarded the Eric Prystowsky Clinical Research Award. Drs. Mahajan, Pathak, and Wong are supported by Early Career Fellowships from the National Health and Medical Research Council (NHMRC). Dr. Mahajan is supported by the National Heart Foundation (NHF) of Australia and by the Leo J. Mahar Lectureship from the University of Adelaide. Ms. Middeldorp is supported by a post-graduate scholarship from the NHMRC and the Robert J. Craig Scholarship from the University of Adelaide. Mr. Agbaedeng is supported by the Leo J. Mahar Scholarship from the University of Adelaide. Dr. Linz is supported by a Beacon Fellowship from the University of Adelaide. Dr. Lau is supported by the Robert J. Craig Lectureship from the University of Adelaide. Dr. Sanders is supported by Practitioner Fellowships from the NHMRC and NHF of Australia. This study was supported by funds from the Centre of Heart Rhythm Disorders at the University of Adelaide. This study was presented at the Annual Scientific Sessions of the Heart Rhythm Society, May 2015, Boston, Massachusetts and was awarded the Eric Prystowsky Clinical Research Award. Dr. Mahajan reports that the University of Adelaide has received on his behalf lecture and/or consulting fees and research funding from Abbott and Medtronic. Dr. de Groot has been a consultant for Atricure and Daiichi Sankyo; and has received research grants from Boston Scientific, Medtronic, Abbott, and St. Jude Medical. Dr. Lau reports that the University of Adelaide has received on his behalf lecture and/or consulting fees from Abbott, Pfizer, Bayer, and Boehringer Ingelheim; and has received research funding from Abbott. Dr. Sanders has served on the advisory board of Biosense-Webster, Medtronic, Abbott, Boston Scientific, and CathRx; reports that the University of Adelaide has received on his behalf lecture and/or consulting fees from Biosense-Webster, Medtronic, Abbott, and Boston Scientific; and that the University of Adelaide has received on his behalf research funding from Medtronic, Abbott, Boston Scientific, Biotronik, and Liva Nova. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. William Stevenson, MD, served as Guest Editor for this paper.