Journal article
Androgen and Oestrogen Affect the Expression of Long Non-Coding RNAs During Phallus Development in a Marsupial
Yu Chen, Yoko Kuroki, Geoff Shaw, Andrew J Pask, Hongshi Yu, Atsushi Toyoda, Asao Fujiyama, Marilyn B Renfree
NON-CODING RNA | MDPI | Published : 2019
DOI: 10.3390/ncrna5010003
Abstract
There is increasing evidence that long non-coding RNAs (lncRNAs) are important for normal reproductive development, yet very few lncRNAs have been identified in phalluses so far. Unlike eutherians, phallus development in the marsupial tammar wallaby occurs post-natally, enabling manipulation not possible in eutherians in which differentiation occurs in utero. We treated with sex steroids to determine the effects of androgen and oestrogen on lncRNA expression during phallus development. Hormonal manipulations altered the coding and non-coding gene expression profile of phalluses. We identified several predicted co-regulatory lncRNAs that appear to be co-expressed with the hormone-responsive c..
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Funding Acknowledgements
This study was supported by a grant from the Australian National Health and Medical Research Council to MBR, AJP, GS, HY and JDW and was supported, in part, by the Transdisciplinary Research Integration Center (TRIC) Project of the Research Organization of Information and Systems (ROIS), Japan.