Neutrophils and Malaria
Elizabeth H Aitken, Agersew Alemu, Stephen J Rogerson
FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2018
Neutrophils are abundant in the circulation and are one of the immune system's first lines of defense against infection. There has been substantial work carried out investigating the role of neutrophils in malaria and it is clear that during infection neutrophils are activated and are capable of clearing malaria parasites by a number of mechanisms. This review focuses on neutrophil responses to human malarias, summarizing evidence which helps us understand where neutrophils are, what they are doing, how they interact with parasites as well as their potential role in vaccine mediated immunity. We also outline future research priorities for these, the most abundant of leukocytes.
Related Projects (2)
Awarded by National Health and Medical Research Council of Australia
Awarded by Centre for Research Excellence in Malaria Elimination
The authors' work is supported by grants from the National Health and Medical Research Council of Australia (APP1092789 and APP1143946), and by the Centre for Research Excellence in Malaria Elimination (APP1134989).