Journal article

The SMILES trial: an important first step

Felice N Jacka, Adrienne O'Neil, Catherine Itsiopoulos, Rachelle Opie, Sue Cotton, Mohammadreza Mohebbi, David Castle, Sarah Dash, Cathrine Mihalopoulos, Mary Lou Chatterton, Laima Brazionis, Olivia M Dean, Allison Hodge, Michael Berk

BMC MEDICINE | BMC | Published : 2018

Abstract

The SMILES trial was the first intervention study to test dietary improvement as a treatment strategy for depression. Molendijk et al. propose that expectation bias and difficulties with blinding might account for the large effect size. While we acknowledge the issue of expectation bias in lifestyle intervention trials and indeed discuss this as a key limitation in our paper, we observed a strong correlation between dietary change and change in depression scores, which we argue is consistent with a causal effect and we believe unlikely to be an artefact of inadequate blinding. Since its publication, our results have been largely replicated and our recent economic evaluation of SMILES suggest..

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Grants

Awarded by National Health and Medical Research (NHMRC) Council Career Development Fellowship


Awarded by NHMRC Senior Principal Research Fellowship


Awarded by Future Leader Fellowship from the Heart Foundation, Australia


Awarded by R.D. Wright Biomedical Research Fellowship


Funding Acknowledgements

FNJ is supported by a National Health and Medical Research (NHMRC) Council Career Development Fellowship (2) (#1108125). MB is supported by an NHMRC Senior Principal Research Fellowship (#1059660). AO is supported by a Future Leader Fellowship (#101160) from the Heart Foundation, Australia. OD is supported by a R.D. Wright Biomedical Research Fellowship (#1145634).