Tissue-resident memory CD8 T cells promote melanoma–immune equilibrium in skin

SL Park; A Buzzai; J Rautela; JL Hor; K Hochheiser; M Effern; N McBain; T Wagner; J Edwards; R McConville; JS Wilmott; RA Scolyer; T Tüting; U Palendira; D Gyorki; SN Mueller; ND Huntington; S Bedoui; M Hölzel; LK Mackay; J Waithman; T Gebhardt

Journal article

Tissue-resident memory CD8 T cells promote melanoma–immune equilibrium in skin

SL Park, A Buzzai, J Rautela, JL Hor, K Hochheiser, M Effern, N McBain, T Wagner, J Edwards, R McConville, JS Wilmott, RA Scolyer, T Tüting, U Palendira, D Gyorki, SN Mueller, ND Huntington, S Bedoui, M Hölzel, LK Mackay Show all

Nature | NATURE PUBLISHING GROUP | Published : 2019

DOI: 10.1038/s41586-018-0812-9

Abstract

The immune system can suppress tumour development both by eliminating malignant cells and by preventing the outgrowth and spread of cancer cells that resist eradication1. Clinical and experimental data suggest that the latter mode of control—termed cancer–immune equilibrium1—can be maintained for prolonged periods of time, possibly up to several decades2–4. Although cancers most frequently originate in epithelial layers, the nature and spatiotemporal dynamics of immune responses that maintain cancer–immune equilibrium in these tissue compartments remain unclear. Here, using a mouse model of transplantable cutaneous melanoma5, we show that tissue-resident memory CD8+ T cells (TRM cells) promo..

View full abstract

University of Melbourne Researchers

Simone Park Author

Nathan McBain Author

Teagan McGivern Author

David Gyorki Author

Grants

Awarded by Melanoma Research Alliance

Funding Acknowledgements

We thank F. Carbone and A. Kallies for critical reading of our manuscript. This work was supported by the University of Melbourne (Elizabeth and Vernon Puzey Scholarship to S.L.P); the Sylvia and Charles Viertel Charitable Foundation (fellowship to T.G.); the Australian National Health and Medical Research Council (fellowships to L.K.M., R.A.S., J.S.W, S.N.M. and N.D.H; grants to R.A.S., J.S.W (1093017) and N.D.H. (1124907, 1124784)); the Cancer Councils of Victoria (grant to N.D.H. (1145730)) and Western Australia (fellowship to J.W.); BHP (grant to J.W.); and the German Research Foundation (GRK2168 Bo&MeRanG Faculty Support Scholarship to M.E., Excellence Cluster ImmunoSensation to M.H. and Program Grant SFB 854/TP27 to T.T.). K.H. is a Rhian and Paul Brazis Fellow in Translational Melanoma Immunology. N.D.H. was supported by the Harry J. Lloyd Charitable Trust, Melanoma Research Alliance, Ian Potter Foundation, Tour de Cure and Cancer Research Institute (USA) and the Victorian State Government Operational Infrastructure Support Scheme.