Perturbation of mucosal-associated invariant T cells and iNKT cells in HIV infection
Jennifer A Juno, Chansavath Phetsouphanh, Paul Klenerman, Stephen J Kent
CURRENT OPINION IN HIV AND AIDS | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019
PURPOSE OF REVIEW: To analyze the possible role that the 'unconventional' T-cell populations mucosal-associated invariant T cell (MAIT) and iNKT cells play during HIV infection and following antiretroviral therapy (ART) treatment. RECENT FINDINGS: A substantial body of evidence now demonstrates that both MAIT and iNKT cells are depleted in blood during HIV infection. The depletion and dysfunction of MAIT and iNKT cells are only partially restored by suppressive ART, potentially contributing to HIV-related comorbidities. SUMMARY: The deficiency and dysfunction of MAIT and iNKT T-cell subsets likely impact on immunity to important coinfections including Mycobacterium tuberculosis. This undersc..View full abstract
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Awarded by Wellcome Trust
J.A.J. and S.J.K. are supported by fellowships from the NHMRC. P.K. and C.P. are supported by the Wellcome Trust (WT109965MA) an NIHR Senior Fellowship (P.K.), and the NIHR Biomedical Research Centre, Oxford.