Adolescent Inhalant Abuse Results in Adrenal Dysfunction and a Hypermetabolic Phenotype with Persistent Growth Impairments
Rose Crossin, Zane B Andrews, Natalie A Sims, Terence Pang, Michael Mathai, Jonathan H Gooi, Aneta Stefanidis, Brian J Oldfield, Andrew J Lawrence, Jhodie R Duncan
NEUROENDOCRINOLOGY | KARGER | Published : 2018
BACKGROUND/AIMS: Abuse of toluene products (e.g., glue-sniffing) primarily occurs during adolescence and has been associated with appetite suppression and weight impairments. However, the metabolic phenotype arising from adolescent inhalant abuse has never been fully characterised, and its persistence during abstinence and underlying mechanisms remain unknown. METHODS: Adolescent male Wistar rats (post-natal day 27) were exposed to inhaled toluene (10,000 ppm) (n = 32) or air (n = 48) for 1 h/day, 3 days/week for 4 weeks, followed by 4 weeks of abstinence. Twenty air rats were pair-fed to the toluene group, to differentiate the direct effects of toluene from under-nutrition. Food intake, wei..View full abstract
Awarded by Australian National Health and Medical Research Council (NHMRC)
The research was supported by the Australian National Health and Medical Research Council (NHMRC) (940835), of which A.J.L. is a Principal Research Fellow (1116930), Z.B.A. is a Career Development Fellow (1084344), and N.A.S. was a Senior Research Fellow (1019803). Support was also received from the Australian Department of Education and Training, from whom R.C. receives a scholarship through the Research Training Program, and the Victorian Government's Operational Infrastructure Support Scheme. The funding bodies had no involvement in the design, analysis, and decision to publish. There are no conflicts of interest or financial disclosures related to this work.