Journal article

Selective Loss of Levator Ani and Leg Muscle Volumes in Men Undergoing Androgen Deprivation Therapy

Ada S Cheung, Christopher Cunningham, Dong-Kyoon Daniel Ko, Vivian Ly, Hans Gray, Rudolf Hoermann, Boyd JG Strauss, Ebrahim Bani Hassan, Gustavo Duque, Peter Ebeling, Marcus G Pandy, Jeffrey D Zajac, Mathis Grossmann

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | ENDOCRINE SOC | Published : 2019

Abstract

CONTEXT: Androgen deprivation therapy (ADT) for prostate cancer (PCa) leads to a selective loss of leg muscle function during walking. Rodent models of ADT have demonstrated that the levator ani is exquisitely androgen sensitive. OBJECTIVE: To determine whether the high androgen responsiveness of the levator ani muscle documented in rodents is evolutionarily conserved and ADT is associated with a selective loss in leg muscle volume. DESIGN: Prospective longitudinal case-control study. SETTING: Tertiary referral hospital. PARTICIPANTS: Thirty-four men newly beginning ADT and 29 age-matched controls with PCa. MAIN OUTCOME MEASURES: The muscle volumes in liters of the levator ani and primary mu..

View full abstract

Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by NHMRC


Awarded by NHMRC Career Development Fellowship


Funding Acknowledgements

The present study was supported by the National Health and Medical Research Council of Australia (NHMRC)(project grant 1006407). A.S.C. was supported by an NHMRC scholarship (grant 1017233), NHMRC early career fellowship (grant 1143333), and a Viertel Charitable Foundation Clinical Investigator Award. M.G. was supported by a NHMRC Career Development Fellowship (grant 1024139).